Characteristics of prostate cancer in men less than 50-year-old

A literature review by French doctors:

Prog Urol. 2009 Dec;19(11):803-9. Epub 2009 Jun 4.

[Characteristics of prostate cancer in men less than 50-year-old.]

[Article in French]

Peyromaure M, Valéri A, Rebillard X, Beuzeboc P, Richaud P, Soulié M, Salomon L;
les membres du CCAFU.

Service d'urologie, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014
Paris, France.

OBJECTIVE: To report the characteristics of prostate cancer (PCa) in men less
than 50-year-old and the results of different treatments of PCa in this
population. METHOD: A bibliographic research was performed using Pubmed database.
The keywords that we used were: prostate cancer, age, young, radical
prostatectomy, brachytherapy, radiotherapy, active surveillance. The studies
which included a significant number of patients were selected. A total of 38
articles were used as bibliographic references. RESULTS: PCa in young men does
not seem to have different characteristics than in older men. Nevertheless, young
men seem to have a lower risk of severe urinary and sexual sequelae, particularly
following radical prostatectomy. CONCLUSIONS: There is no recommendation
regarding management of PCa in men less than 50-year-old. In case of localized
cancer, two options may be considered. First option consists in decreasing the
urinary and sexual complications of radical prostatectomy. A minimally-invasive
treatment, such as brachytherapy or even active surveillance, may reach this
objective. Second option consists in being more aggressive. To propose a radical
prostatectomy offers to the patient the possibility of salvage radiation therapy
in case of locally-advanced tumor or local recurrence.

PMID: 19945663 [PubMed - in process]