49% of the patients failed salvage radiation during the study, after an average of 30.7 months. Those patients were then put on ADT. 14% of those patients successfully controlled their PSA with ADT for 20.7 months, leaving 86% who controlled their PSA for over 3 years.
Fast doubling times (less than 3 months) were predictive of RT failure.
Treatment failure and clinical progression after salvage therapy in men with biochemical recurrence after radical prostatectomy: radiotherapy vs androgen deprivation.
Departments of Urology and Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.This is personally troubling to me on a couple of points--first, my doubling time was very fast--well under 90 days. Secondly, this study reinforces my belief that I'm far from out of the woods. I'm a little under three years out from the end of salvage radiation, just about the point, on average, where men who fail RT see their PSA rise again. Obviously, I need to keep monitoring my PSA. If it begins to rise and the doubling time is as fast as it was before treatment, I should probably not delay hormone therapy.